Summary for peptidase M01.030: aminopeptidase N2 (insect)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates


MEROPS Nameaminopeptidase N2 (insect)
Name and HistoryThe bacterium Bacillus thuringiensis is a pathogen that infects insects and is widely used to control crop pests. The bacterium produces toxins known as ICPs (insecticidal crystal proteins) which bind to midgut epithelial cells causing them to lyse colloidosmotically. Aminopeptidase N2 is an insect protein expressed on the surface of midgut epithelial cells that acts as a receptor for the ICP. Aminopeptidase N2 from the midgut epithelium of the diamondback moth Plutella xylostella, which is a serious pest of cabbages and other cruciferous plants, has been shown to bind to the ICP Cry1Ab5 (Denolf et al., 1997).
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M1 >> Subfamily (none) >> M01.030
Holotypeaminopeptidase N2 (insect) (Manduca sexta), Uniprot accession P91885 (peptidase unit: 269-474), MERNUM MER0003500
History Identifier created: MEROPS 8.0 (8 January 2008)
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
SpecificityAminopeptidase N2 has not been characterized biochemically.
StructureAminopeptidase N2 is membrane-associated via a C-terminal glycosylphosphatidylinositol anchor (Denolf et al., 1997).