Summary for peptidase M02.004: angiotensin-converting enzyme peptidase unit 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameangiotensin-converting enzyme peptidase unit 2
Other namespeptidyl-dipeptidase A, C domain, germinal peptidyl-dipeptidase A, testicular angiotensin-converting enzyme, tACE, peptidyl-dipeptidase A peptidase unit 2
Domain architecture
MEROPS Classification
Parent M02.004 is one peptidase unit of the compound peptidase XM02-001. Other units of XM02-001 are M02.001
Classification Clan MA >> Subclan MA(E) >> Family M2 >> Subfamily (none) >> M02.004
Holotypeangiotensin-converting enzyme peptidase unit 2 (Homo sapiens), Uniprot accession P12821 (peptidase unit: 641-1258), MERNUM MER0001019
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00134
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.15 (Peptidyl-dipeptidases) >> Peptidase 3.4.15.1
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Araujo et al., 2000)
mouse: active (Vazeux et al., 2001)
PhysiologyThis is the more C-terminal peptidase unit of the two peptidase units in the somatic form of angiotensin-converting enzyme, and is the sinngle peptidase unit in the germinal form of the enzyme. Angiotensin-converting enzyme is an ectoenzyme active in the conversion of angiotensin I to hypertensive angiotensin II, and degradation of bradykinin and other bioactive peptides. An insertion/deletion polymorphism is associated with left ventricular hypertrophy.
KnockoutMice in which the germinal form of angiotensin-converting enzyme is entirely secreted have low blood pressure, renal vascular thickening, and a urine concentrating defect (Esther et al., 1997), similarly to mice completely lacking angiotensin-converting enzyme (Esther et al., 1996).
Pharmaceutical relevanceThe somatic form of angiotensin-converting enzyme containing this peptidase unit together with peptidase unit 1 (M02.001) is a drug target for the control of hypertension.
Other databases TREEFAMhttp://www.treefam.org/family/TF312861
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ACE 17q23 ENSG00000159640 1636 ACE 106180
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ace 11:E1 ENSMUSG00000020681 11421 MGI:87874