Summary for peptidase M03.002: neurolysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Nameneurolysin
Other namesendopeptidase 24.16, microsomal endopeptidase, mitochondrial oligopeptidase, neurotensin-degrading enzyme, neurotensin endopeptidase, oligopeptidase M, soluble angiotensin II-binding protein, thimet oligopeptidase II
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M3 >> Subfamily A >> M03.002
Holotypeneurolysin (Rattus norvegicus), Uniprot accession P42676 (peptidase unit: 26-704), MERNUM MER0001942
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00137
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.16
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Barrett & Dando, 2004)
mouse: active (by similarity to rat) (Serizawa et al., 1995)
PhysiologyIntracellular oligopeptide degradation. Proposed role in destruction of several bioactive peptides.
Pathways KEGGRenin-angiotensin system
Other databases TREEFAMhttp://www.treefam.org/family/TF300459
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternG/F/spgr/PScissile bondFsr/Rpi/Q/- (based on 128 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 70 2 15 0 1 1 0 2
Pro 14 8 23 68 1 28 1 0
Ala 2 3 3 5 3 3 2 1
Val 0 0 0 0 0 0 0 0
Leu 1 2 1 5 3 6 12 2
Ile 1 1 3 1 6 11 4 0
Met 0 0 0 0 0 0 1 1
Phe 1 60 3 17 59 3 13 2
Tyr 0 0 1 6 11 0 1 0
Trp 0 0 0 0 1 2 2 1
Ser 0 2 56 4 21 1 2 1
Thr 0 1 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 9 2 2 1 1 1 1 2
Gln 0 1 1 1 2 3 74 5
Asp 0 1 1 1 1 0 2 2
Glu 0 1 1 1 1 1 2 1
Lys 3 14 4 2 1 2 0 0
Arg 7 14 13 15 14 61 4 7
His 0 1 1 1 1 2 0 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
NLN 5q12.3 ENSG00000123213 57486 NLN
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Nln 13:D1 ENSMUSG00000021710 75805 MGI:1923055