Summary for peptidase M03.006: mitochondrial intermediate peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Namemitochondrial intermediate peptidase
Other namesAt5g51540 (Arabidopsis thaliana)-like peptidase, DDB_G0295743 g.p. (Dictyostelium discoideum), MAL13P1.184 g.p. (Plasmodium falciparum), MIPEP g.p. (Homo sapiens), octapeptidyl aminopeptidase 1, OCT1 g.p. (Saccharomyces cerevisiae), Y67H2A.7 g.p. (Caenorhabditis elegans)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M3 >> Subfamily A >> M03.006
Holotypemitochondrial intermediate peptidase (Saccharomyces cerevisiae), Uniprot accession P35999 (peptidase unit: 59-772), MERNUM MER0001156
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00141
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.59
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Isaya, 2004)
mouse: active (by similarity to rat) (Isaya, G. et al., 1992)
PhysiologyProcessing of some mitochondrial proteins during import from cytosol
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/p/-/fqnScissile bondsa/kpqa/vf/- (based on 16 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 3 0 2 0 1 2
Pro 2 5 0 1 0 3 0 1
Ala 3 1 2 0 3 2 0 2
Val 2 2 2 0 0 0 6 1
Leu 0 0 3 2 0 0 0 2
Ile 0 0 1 0 0 0 0 0
Met 0 1 0 1 0 0 0 0
Phe 0 0 0 4 1 0 3 1
Tyr 0 1 0 1 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 1 1 0 0 6 1 1 1
Thr 2 1 0 0 0 0 1 0
Cys 0 0 0 0 0 0 0 0
Asn 1 0 2 3 2 0 0 0
Gln 1 2 1 4 2 3 0 3
Asp 0 0 0 0 0 0 1 0
Glu 0 0 0 0 0 0 1 0
Lys 2 0 0 0 0 7 2 0
Arg 1 1 1 0 0 0 0 3
His 0 0 1 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MIPEP 13q12 ENSG00000027001 4285 MIPEP 602241
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mipep 14:C3 ENSMUSG00000021993 70478 MGI:1917728