Summary for peptidase M04.007: coccolysin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Namecoccolysin
Other namesgelatinase (Enterococcus faecalis), gelE g.p. (Enterococcus faecalis), intracellular endopeptidase (Enterococcus, Streptococcus thermophilus)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M4 >> Subfamily (none) >> M04.007
Holotypecoccolysin (Enterococcus faecalis), Uniprot accession Q833V7 (peptidase unit: 176-491), MERNUM MER0002810
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00146
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.30
EnzymologyBRENDA database
Proteolytic eventsCutDB database (7 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bondlfi/-/-/- (based on 23 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 2 1 2 0 2 3 0
Pro 2 3 1 2 1 0 4 2
Ala 3 0 1 2 1 0 0 2
Val 4 3 2 0 2 3 3 1
Leu 2 0 0 2 8 0 4 1
Ile 0 2 0 0 4 0 0 0
Met 0 0 0 0 0 2 0 1
Phe 0 3 2 3 6 1 1 3
Tyr 1 1 2 2 1 2 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 3 1 0 1 1 1
Thr 1 2 1 2 0 2 1 1
Cys 0 0 0 0 0 0 0 0
Asn 1 1 1 1 0 0 0 1
Gln 1 1 4 1 0 1 2 4
Asp 1 0 0 2 0 3 0 1
Glu 1 0 4 0 0 0 2 1
Lys 1 1 0 0 0 1 0 1
Arg 3 4 0 0 0 1 0 0
His 0 0 1 3 0 3 0 0