Summary for peptidase M04.009: aureolysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Nameaureolysin
Other nameselastase (Staphylococcus), neutral proteinase (Staphylococcus aureus), SepP1 g.p. (Staphylococcus aureus), sepA g.p. (Staphylococcus epidermidis)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M4 >> Subfamily (none) >> M04.009
Holotypeaureolysin (Staphylococcus aureus), Uniprot accession P81177 (peptidase unit: 210-509), MERNUM MER0004711
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00147
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.29
EnzymologyBRENDA database
Proteolytic eventsCutDB database (5 cleavages)
PhysiologyActivates precursor of glutamyl endopeptidase of organism.
Pharmaceutical relevanceSeveral possible roles in pathology of S. aureus infection.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bondlfiv/-/-/- (based on 24 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 2 0 5 0 2 3 2
Pro 1 1 0 0 0 1 1 1
Ala 2 3 1 2 0 2 2 1
Val 1 2 0 0 3 6 0 1
Leu 4 2 2 1 10 1 2 1
Ile 1 0 0 0 4 1 0 2
Met 0 0 1 0 0 0 1 0
Phe 1 2 2 2 5 1 0 1
Tyr 0 0 0 2 1 2 2 0
Trp 0 0 0 0 0 0 0 0
Ser 1 0 3 2 0 1 0 3
Thr 2 0 1 0 0 1 0 3
Cys 1 0 0 0 0 0 0 0
Asn 0 2 1 1 0 0 2 0
Gln 0 0 2 0 0 0 1 2
Asp 0 0 0 0 0 1 1 1
Glu 2 3 2 0 0 1 3 0
Lys 0 0 4 5 1 1 0 1
Arg 1 3 1 2 0 0 1 1
His 0 0 0 2 0 0 0 0