Summary for peptidase M05.001: mycolysin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Namemycolysin
Other namesneutral endopeptidase (Streptomyces cacaoi)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M5 >> Subfamily (none) >> M05.001
Holotypemycolysin (Streptomyces cacaoi), Uniprot accession P20910 (peptidase unit: 206-550), MERNUM MER0001049
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00149
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.31
EnzymologyBRENDA database
PhysiologyBacterial nutrition.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/fgScissile bondlfv/-/-/- (based on 12 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 2 1 3 0 0 2 1
Pro 0 0 0 0 0 0 1 1
Ala 1 1 0 1 0 0 0 1
Val 1 1 0 0 2 2 0 1
Leu 1 1 1 1 5 1 1 0
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 1 4 3 1 0 0
Tyr 0 0 1 1 1 2 1 0
Trp 0 0 0 0 1 0 0 0
Ser 0 0 1 0 0 0 0 1
Thr 0 0 0 0 0 1 1 1
Cys 0 0 0 0 0 0 0 0
Asn 0 1 0 0 0 1 0 0
Gln 0 0 1 0 0 0 1 0
Asp 0 0 0 0 0 0 0 0
Glu 2 1 1 0 0 0 1 1
Lys 0 0 0 0 0 0 0 1
Arg 1 1 1 0 0 0 0 0
His 0 0 0 2 0 0 0 1