Summary for peptidase M09.002: bacterial collagenase G/A

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

Names
MEROPS Namebacterial collagenase G/A
Other namesbacterial collagenase, class I, clostridiopeptidase A, Clostridium histolyticum collagenase, colA g.p. (Clostridium perfringens), collagenase A, collagenase Clostridium histolyticum, collagenase I, colG g.p. (Clostridium histolyticum), microbial collagenase, class I, Xiaflex
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M9 >> Subfamily B >> M09.002
Holotypebacterial collagenase G/A (Clostridium histolyticum) (peptidase unit: 319-798), MERNUM MER0005663
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00153
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.3
EnzymologyBRENDA database
Proteolytic eventsCutDB database (2 cleavages)
BiotechnologyMany uses, including tissue cell dispersion.
PhysiologyRequired for bacterial nutrition; may act in tissue invasion by this pathogen.
Pharmaceutical relevanceAgent under investigation for treatment of bed sores, and for chemonucleolysis of herniated intervertebral disks.