Summary for peptidase M10.001: matrix metallopeptidase-1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Substrates Inhibitors Pharma

 

Names
MEROPS Namematrix metallopeptidase-1
Other namescollagenase 1, interstitial collagenase, matrix metalloproteinase 1, MMP-1, vertebrate collagenase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.001
Holotypematrix metallopeptidase-1 (Homo sapiens), Uniprot accession P03956 (peptidase unit: 98-276), MERNUM MER0001063
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00154
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.7
EnzymologyBRENDA database
Proteolytic eventsCutDB database (31 cleavages)
PhysiologyRole in turnover of most types of collagen.
Pharmaceutical relevanceDrug target for prevention of pathological tissue damage. IgG autoantibodies in sera from systemic sclerosis patients inhibited the enzyme, and may have contributed to fibrosis (Sato et al., 2003).
Pathways KEGGBladder cancer
KEGGPathways in cancer
KEGGPPAR signaling pathway
KEGGRheumatoid arthritis
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/MMP1
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/pa/-/-Scissile bondli/-/-/- (based on 75 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 13 2 3 17 0 3 14 6
Pro 2 28 3 2 2 1 2 7
Ala 10 15 6 13 6 6 12 10
Val 3 6 5 6 5 7 7 5
Leu 7 5 10 4 22 7 4 4
Ile 2 3 2 0 14 3 2 4
Met 0 1 1 1 5 3 0 1
Phe 4 0 1 3 5 3 0 2
Tyr 0 2 1 4 0 3 2 0
Trp 0 0 0 0 0 1 0 0
Ser 3 3 6 3 3 6 3 4
Thr 6 0 2 1 2 3 7 6
Cys 0 0 0 1 0 0 1 2
Asn 0 0 4 3 0 3 3 1
Gln 4 2 10 2 3 3 4 9
Asp 4 1 2 4 2 1 1 2
Glu 5 1 10 1 1 2 6 4
Lys 1 2 4 4 0 8 3 2
Arg 3 3 3 4 1 8 2 3
His 2 1 0 2 1 2 2 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMP1 11q22-q23 ENSG00000149968 4312 MMP1 120353