Summary for peptidase M10.002: matrix metallopeptidase-8

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Substrates Inhibitors Pharma

 

Names
MEROPS Namematrix metallopeptidase-8
Other namescollagenase 2, matrix metalloproteinase 8, MMP-8, neutrophil collagenase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.002
Holotypematrix metallopeptidase-8 (Homo sapiens), Uniprot accession P22894 (peptidase unit: 97-275), MERNUM MER0001084
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00155
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.34
EnzymologyBRENDA database
Proteolytic eventsCutDB database (72 cleavages)
Activity statushuman: active (Tschesche et al., 2004)
mouse: active (Balbin et al., 1998)
PhysiologyRole in turnover of extracellular matrix proteins.
KnockoutMice deficient in collagenase 2 developed normally, but males showed a high incidence of skin tumors (Balbin et al., 2003).
Pharmaceutical relevanceDrug target for prevention of pathological tissue damage.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/MMP8
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterng/pas/-/gScissile bondl/-/g/- (based on 114 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 36 2 3 35 1 2 38 7
Pro 3 44 9 10 0 2 3 11
Ala 6 16 9 8 8 9 13 13
Val 6 6 3 2 8 7 4 4
Leu 8 7 10 4 37 5 3 13
Ile 3 2 1 0 13 5 4 5
Met 0 1 3 0 1 5 0 1
Phe 5 5 3 9 11 5 0 1
Tyr 1 0 2 4 2 1 1 0
Trp 0 0 1 0 0 4 1 0
Ser 6 16 16 6 4 12 7 6
Thr 7 0 1 3 2 4 8 8
Cys 0 0 0 0 0 0 2 0
Asn 3 2 4 9 3 4 1 5
Gln 4 3 15 2 5 12 8 11
Asp 4 1 2 4 2 2 2 5
Glu 5 3 6 6 1 3 4 5
Lys 9 4 12 9 7 9 4 1
Arg 2 0 11 1 6 17 2 8
His 2 2 3 2 2 2 3 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMP8 11q21-q22 ENSG00000118113 4317 MMP8 120355
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mmp8 9:A1 ENSMUSG00000005800 17394 MGI:1202395