Summary for peptidase M10.006: matrix metallopeptidase-10 (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Substrates Inhibitors Pharma

 

Names
MEROPS Namematrix metallopeptidase-10 (Homo sapiens-type)
Other namesmatrix metalloproteinase 10, MMP-10, stromelysin 2, transin-2 (Homo sapiens-type)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.006
Holotypematrix metallopeptidase-10 (Homo sapiens-type), Uniprot accession P09238 (peptidase unit: 97-278), MERNUM MER0001072
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00159
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.22
EnzymologyBRENDA database
Proteolytic eventsCutDB database (16 cleavages)
Activity statushuman: active (Matrisian, 2004)
mouse: active (Gack et al., 1994)
PhysiologyRole in turnover of extracellular matrix proteins.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/MMP10
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/Psg/-/-Scissile bondlf/-/-/- (based on 19 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 2 3 3 0 0 2 4
Pro 1 10 0 1 0 0 0 0
Ala 0 1 1 2 1 1 2 4
Val 0 1 0 0 0 2 0 1
Leu 2 1 3 1 6 1 2 0
Ile 1 0 2 0 1 0 0 1
Met 0 0 1 0 0 1 0 0
Phe 0 0 0 0 4 1 0 2
Tyr 0 0 0 1 0 0 0 1
Trp 0 0 0 0 0 1 0 0
Ser 2 4 2 1 1 4 1 0
Thr 0 0 0 0 0 0 5 2
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 2 1 0 0 0
Gln 0 0 1 2 2 4 2 2
Asp 3 0 1 0 0 1 0 0
Glu 1 0 1 1 0 0 2 1
Lys 0 0 2 2 0 1 1 0
Arg 4 0 1 1 3 1 1 1
His 1 0 1 2 0 0 1 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMP10 11q22.3-q23 ENSG00000166670 4319 MMP10 185260