Summary for peptidase M10.007: matrix metallopeptidase-11

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namematrix metallopeptidase-11
Other namesmatrix metalloproteinase 11, MMP-11, stromelysin 3
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.007
Holotypematrix metallopeptidase-11 (Homo sapiens), Uniprot accession P24347 (peptidase unit: 94-274), MERNUM MER0001075
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00160
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (4 cleavages)
Activity statushuman: active (Pei & Weiss, 2004)
mouse: active (Noel et al., 2000)
PhysiologyRole in turnover of extracellular matrix proteins.
KnockoutAccelerated neointima formation after electric injury of the femoral artery has been detected in mice with stromelysin-3 gene inactivation, but the mechanisms by which this enzyme could impair elastin degradation and cellular migration are unknown (Lijnen et al., 1999).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/MMP11
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/a/a/aScissile bondl/-/-/- (based on 21 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 2 0 1 0 0 1
Pro 4 3 1 1 0 0 1 2
Ala 2 7 6 8 1 1 2 4
Val 2 0 2 0 1 2 0 1
Leu 1 0 2 1 6 2 5 1
Ile 1 1 0 0 2 3 1 2
Met 0 0 1 0 1 0 0 1
Phe 1 0 0 1 4 1 0 0
Tyr 1 1 0 0 3 0 0 1
Trp 0 0 0 0 0 1 0 0
Ser 1 2 1 2 1 1 4 4
Thr 0 1 3 1 1 3 0 0
Cys 1 0 0 1 0 0 0 0
Asn 0 1 0 3 0 0 2 0
Gln 0 1 2 0 0 3 1 0
Asp 1 1 0 0 0 1 2 1
Glu 2 3 1 1 0 3 1 2
Lys 1 0 0 0 0 0 1 0
Arg 0 0 0 0 0 0 0 1
His 2 0 0 2 0 0 1 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMP11 22q11.2 ENSG00000099953 4320 MMP11 185261
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mmp11 10:C1 ENSMUSG00000000901 17385 MGI:97008