Summary for peptidase M10.008: matrix metallopeptidase-7

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namematrix metallopeptidase-7
Other namesmatrilysin, matrin (obs.), matrix metallopeptidase-7, matrix metalloproteinase 7, MMP-7, putative metalloproteinase-1, uterine metalloendopeptidase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.008
Holotypematrix metallopeptidase-7 (Homo sapiens), Uniprot accession P09237 (peptidase unit: 94-267), MERNUM MER0001092
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00161
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.23
EnzymologyBRENDA database
Proteolytic eventsCutDB database (89 cleavages)
Activity statushuman: active (Woessner, 2004)
mouse: active (Crabbe et al., 1992)
PhysiologyRole in turnover of extracellular matrix proteins.
KnockoutSuppression of expression of matrilysin by antisense methods has shown depression of invasive potential of cancer cells (Yamamoto et al., 1995; Miyazaki et al., 1999). Also, matrilysin knockout mice were dramatically protected from bleomycin-induced pulmonary fibrosis (Zuo et al., 2002).
Pharmaceutical relevanceDrug target for prevention of pathological tissue damage. Research data suggest that matrilysin plays an important role in leukaemia cell invasion (Lynch & McDonnell, 2001).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/MMP7
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/pa/-/-Scissile bondL/-/-/- (based on 196 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 40 28 32 48 9 38 43 36
Pro 16 48 11 12 6 2 6 22
Ala 24 31 34 20 2 21 38 21
Val 9 24 9 2 17 19 16 18
Leu 12 25 20 9 107 6 13 13
Ile 8 7 1 3 19 2 4 7
Met 4 3 4 1 5 4 1 1
Phe 4 2 4 8 11 4 8 5
Tyr 5 1 4 5 9 5 4 5
Trp 0 0 0 0 0 1 2 0
Ser 7 5 12 14 0 14 7 12
Thr 6 1 6 3 1 16 8 7
Cys 1 0 1 2 0 0 0 1
Asn 1 1 5 6 0 2 2 3
Gln 5 5 12 9 0 9 5 6
Asp 6 3 3 14 2 3 9 6
Glu 20 2 17 22 2 11 19 11
Lys 10 1 11 8 4 10 4 7
Arg 5 4 8 9 1 21 4 9
His 8 4 2 1 1 6 2 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMP7 11q21-q22 ENSG00000137673 4316 MMP7 178990
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mmp7 9:A1 ENSMUSG00000018623 17393 MGI:103189