Summary for peptidase M10.009: matrix metallopeptidase-12

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namematrix metallopeptidase-12
Other namesmacrophage elastase, matrix metalloproteinase 12, metalloelastase, MMP-12
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.009
Holotypematrix metallopeptidase-12 (Mus musculus), Uniprot accession P34960 (peptidase unit: 91-272), MERNUM MER0001090
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00162
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.65
EnzymologyBRENDA database
Proteolytic eventsCutDB database (94 cleavages)
Activity statushuman: active (Shapiro et al., 2004)
mouse: active (Shapiro et al., 1992)
PhysiologyRole in turnover of extracellular matrix proteins.
Pharmaceutical relevanceDrug target for prevention of pathological tissue damage.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/MMP12
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterng/pag/ag/gaScissile bondl/-/ga/- (based on 218 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 59 26 46 70 7 51 61 35
Pro 15 69 12 15 6 4 8 21
Ala 32 55 56 47 31 36 58 48
Val 19 14 5 8 20 16 8 16
Leu 16 20 17 4 69 6 14 17
Ile 3 3 4 1 14 8 4 10
Met 1 0 4 1 2 2 0 1
Phe 3 1 11 5 10 6 5 7
Tyr 3 1 6 3 14 5 7 3
Trp 0 0 1 0 1 2 1 0
Ser 6 8 6 7 4 14 10 9
Thr 6 4 3 6 5 8 9 7
Cys 2 0 0 0 1 1 0 1
Asn 6 2 2 8 2 3 3 7
Gln 6 7 11 6 7 11 5 6
Asp 4 0 1 2 2 2 4 4
Glu 7 4 11 9 2 5 5 7
Lys 18 2 14 17 16 21 7 9
Arg 8 1 4 4 3 13 6 9
His 2 1 4 5 2 3 2 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMP12 11q22.2-q22.3 ENSG00000110347 4321 MMP12 601046
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mmp12 9:A1 ENSMUSG00000049723 17381 MGI:97005