Summary for peptidase M10.013: matrix metallopeptidase-13

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namematrix metallopeptidase-13
Other namesAgMMP3 (Anopheles gambiense), collagenase 3, matrix metalloproteinase 13, MMP-13, rat collagenase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.013
Holotypematrix metallopeptidase-13 (Mus musculus), Uniprot accession P33435 (peptidase unit: 103-283), MERNUM MER0001067
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00164
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (101 cleavages)
Activity statushuman: active (Henriet & Eeckout, 2004)
mouse: active (Botos et al., 1999)
PhysiologyPlays a role in the turnover of collagen.
KnockoutInactivation of the Mmp13 gene in mice by homologous recombination led to abnormal skeletal growth plate development (Stickens et al., 2004; Inada et al., 2004). A mutation in the human MMP13 gene causes the Missouri variant of spondyloepimetaphyseal dysplasia (Kennedy et al., 2005).
Other databases TREEFAMhttp://www.treefam.org/family/TF315428
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterng/P/-/gScissile bondl/-/ga/- (based on 147 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 49 3 6 66 2 1 56 12
Pro 4 92 20 11 0 4 2 15
Ala 10 17 17 13 9 10 24 7
Val 4 6 9 2 14 12 6 8
Leu 9 9 20 1 49 7 3 12
Ile 4 4 2 1 18 5 1 4
Met 0 0 3 1 11 2 1 1
Phe 2 0 2 1 11 5 1 5
Tyr 0 0 4 1 7 2 4 2
Trp 0 0 1 0 1 2 0 0
Ser 3 3 15 11 4 8 11 4
Thr 6 1 2 3 3 11 5 7
Cys 0 0 0 1 0 0 0 1
Asn 2 0 3 5 1 8 0 2
Gln 4 4 12 4 5 13 2 5
Asp 8 2 0 3 1 4 8 8
Glu 5 1 2 10 2 4 8 7
Lys 1 0 12 6 3 13 2 1
Arg 3 1 14 6 2 24 1 4
His 4 3 2 1 2 6 2 2
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMP13 11q22.3 ENSG00000137745 4322 MMP13 600108
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mmp13 9 ENSMUSG00000050578 17386 MGI:1340026