Summary for peptidase M10.015: membrane-type matrix metallopeptidase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namemembrane-type matrix metallopeptidase-2
Other namesmatrix metalloproteinase 15, membrane-type matrix metalloproteinase 2, MMP-15, matrix metalloproteinase, membrane-type 2, MT2-MMP, SMCP-2, MTMMP-2
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.015
Holotypemembrane-type matrix metallopeptidase-2 (Homo sapiens), Uniprot accession P51511 (peptidase unit: 128-319), MERNUM MER0002383
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00166
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (14 cleavages)
Activity statushuman: active (Yana & Seiki, 2004)
mouse: active (by similarity to human) (Tanaka et al., 1997)
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/MMP15
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/s/-/-Scissile bondls/q/-/- (based on 14 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 2 1 0 0 1 0 2
Pro 0 2 0 1 1 0 0 2
Ala 0 1 2 2 0 2 1 1
Val 1 2 0 0 1 0 0 0
Leu 2 2 2 0 4 0 0 0
Ile 1 0 0 0 2 0 0 2
Met 0 1 1 0 0 1 1 0
Phe 0 0 0 0 0 0 0 1
Tyr 0 0 0 1 0 0 0 0
Trp 0 0 0 0 0 1 0 0
Ser 1 4 0 2 3 1 1 1
Thr 0 0 1 1 0 1 3 1
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 1 1 0 0 0
Gln 1 0 2 0 2 5 2 1
Asp 2 0 3 1 0 0 1 2
Glu 3 0 0 2 0 0 1 0
Lys 0 0 2 2 0 2 1 0
Arg 1 0 0 0 0 0 2 1
His 0 0 0 1 0 0 1 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMP15 16q13-q21 ENSG00000102996 4324 MMP15 602261
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mmp15 8:C5 ENSMUSG00000031790 17388 MGI:109320