Summary for peptidase M10.019: matrix metallopeptidase-20

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Substrates Inhibitors

 

Names
MEROPS Namematrix metallopeptidase-20
Other namesenamelysin, matrix metalloproteinase 20, MMP-20
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.019
Holotypematrix metallopeptidase-20 (Homo sapiens), Uniprot accession O60882 (peptidase unit: 106-287), MERNUM MER0003021
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00167
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (28 cleavages)
Activity statushuman: active (Bartlett, 2004)
mouse: active (Caterina et al., 2000)
PhysiologyIn vitro, enamelysin catalyzes all of the amelogenin cleavages that are known to occur during the secretory stage in vivo, and it is probably the enzyme responsible for the processing of all enamel proteins (Simmer & Hu, 2002).
KnockoutThe enamelysin null mouse has a severe tooth phenotype (Caterina et al., 2002).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/MMP20
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternp/-/l/pScissile bondlm/-/a/- (based on 43 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 5 6 2 0 3 2 2
Pro 19 8 1 13 0 1 6 6
Ala 1 8 3 6 4 2 9 0
Val 2 2 1 0 0 5 0 1
Leu 3 4 14 1 15 6 1 6
Ile 1 3 0 0 0 2 0 0
Met 4 5 1 0 6 2 0 2
Phe 0 1 3 2 1 2 0 0
Tyr 0 0 0 1 5 0 0 2
Trp 0 0 3 3 0 0 1 3
Ser 1 1 2 4 5 0 7 1
Thr 0 0 1 1 0 4 3 1
Cys 0 0 0 0 0 0 0 1
Asn 1 1 0 3 0 0 1 2
Gln 3 0 3 3 4 7 3 10
Asp 2 2 2 0 1 0 3 0
Glu 3 1 1 0 2 5 2 0
Lys 0 0 0 0 0 0 0 3
Arg 0 0 0 4 0 1 0 2
His 1 2 2 0 0 3 5 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMP20 11q22.3 ENSG00000137674 9313 MMP20 604629
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mmp20 9 ENSMUSG00000018620 30800 MGI:1353466