Summary for peptidase M10.029: matrix metallopeptidase-26

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Substrates Pharma

 

Names
MEROPS Namematrix metallopeptidase-26
Other namesendometase, matrilysin-2, matrix metalloproteinase 26, MMP-26
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.029
Holotypematrix metallopeptidase-26 (Homo sapiens), Uniprot accession Q9NRE1 (peptidase unit: 88-261), MERNUM MER0012072
History Identifier created: MEROPS 5.2 (31 August 2000)
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00169
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (12 cleavages)
Activity statushuman: active (Sang, 2004)
mouse: active (by similarity to human) (Park et al., 2002)
Other databases TREEFAMhttp://www.treefam.org/family/TF315428
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/pa/l/aScissile bondlm/-/a/r (based on 17 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 0 0 4 0 0 0 1
Pro 0 8 1 1 0 0 0 2
Ala 0 3 0 5 0 0 6 1
Val 0 0 1 0 2 1 0 0
Leu 0 2 7 1 6 1 0 0
Ile 0 0 1 0 1 1 1 2
Met 0 1 1 0 3 0 0 0
Phe 0 0 0 1 0 1 0 0
Tyr 0 0 0 0 1 0 0 0
Trp 0 0 0 0 0 2 0 0
Ser 3 0 0 0 0 2 1 2
Thr 1 1 0 0 1 1 3 1
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 1 0 0 1 0
Gln 2 0 0 1 1 1 1 1
Asp 0 1 0 0 0 1 1 0
Glu 1 0 2 1 0 1 1 0
Lys 2 1 2 1 0 0 0 0
Arg 0 0 0 0 0 2 0 5
His 1 0 1 1 0 1 2 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMP26 11p15 ENSG00000167346 56547 MMP26 605470