Summary for peptidase M10.056: aeruginolysin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Nameaeruginolysin
Other namesalkaline protease (Pseudomonas aeruginosa), apr g.p. (Pseudomonas aeruginosa)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily B >> M10.056
Holotypeaeruginolysin (Pseudomonas aeruginosa), Uniprot accession Q03023 (peptidase unit: 75-236), MERNUM MER0001097
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00171
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.40
EnzymologyBRENDA database
PhysiologyEnhances attachment of organism to corneal epithelium, playing a major role in pathogenesis.
Pharmaceutical relevanceTarget for vaccine development, and chemotherapy of bacterial infection.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/gScissile bond-/-/-/- (based on 13 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 3 1 4 4 1 1 1
Pro 0 0 0 0 0 1 1 0
Ala 0 1 1 0 1 0 2 1
Val 0 1 2 0 0 1 0 1
Leu 1 2 2 1 2 3 2 2
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 2 3 1 1 2 1 1
Tyr 0 0 0 2 1 0 2 1
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 1 1 0 0
Thr 0 0 0 0 1 1 0 1
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 1 0 0 0 0
Gln 1 0 0 0 1 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 1 1 1 1 1 0 0 0
Lys 0 0 0 0 0 0 1 1
Arg 1 0 1 2 0 1 0 0
His 2 1 0 0 0 2 1 0