Summary for peptidase M12.002: meprin alpha subunit

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Namemeprin alpha subunit
Other namesendopeptidase 2, MEP1A g.p. (Homo sapiens), meprin-a, meprin A, meprin A alpha component, PABA peptide hydrolase alpha component, N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase alpha component
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily A >> M12.002
Holotypemeprin alpha subunit (Mus musculus), Uniprot accession P28825 (peptidase unit: 71-256), MERNUM MER0001108
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00174
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.18
EnzymologyBRENDA database
Proteolytic eventsCutDB database (9 cleavages)
Activity statushuman: active (Bertenshaw & Bond, 2004)
mouse: active (Bertenshaw et al., 2001)
StructurePeptidase unit alpha is one of the two peptidase units, alpha and beta, of meprin A. The peptidase units are present in separate polypeptide chains.
Other databases TREEFAMhttp://www.treefam.org/family/TF315280
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bondd/-/-/- (based on 776 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 62 57 35 77 43 67 93 76
Pro 34 65 47 4 1 129 101 45
Ala 58 54 76 94 79 61 42 51
Val 33 58 73 5 47 62 68 53
Leu 47 59 96 43 50 50 62 72
Ile 25 45 41 3 25 30 52 47
Met 13 16 20 23 15 15 13 11
Phe 27 30 41 43 25 19 18 28
Tyr 15 14 32 25 17 17 13 11
Trp 8 5 8 15 1 11 3 10
Ser 67 43 45 75 55 47 33 37
Thr 36 37 35 8 64 33 52 42
Cys 9 2 7 3 2 2 5 8
Asn 29 23 22 55 16 15 19 26
Gln 39 36 73 50 12 37 24 33
Asp 42 23 22 74 201 45 31 53
Glu 48 32 44 86 91 83 72 99
Lys 92 87 26 17 9 32 49 44
Arg 61 62 9 41 11 10 10 15
His 17 20 23 35 12 11 13 9
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MEP1A 6p21.2-p21.1 ENSG00000112818 4224 MEP1A 600388
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mep1a 17:C1-D1 ENSMUSG00000023914 17287 MGI:96963