Summary for peptidase M12.005: procollagen C-peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameprocollagen C-peptidase
Other namesbone morphogenetic protein 1, BMP 1, mammalian tolloid, mTLD, procollagen C-proteinase, XTLD g.p. (Xenopus laevis)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily A >> M12.005
Holotypeprocollagen C-peptidase (Homo sapiens), Uniprot accession P13497 (peptidase unit: 127-317), MERNUM MER0001113
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00176
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.19
EnzymologyBRENDA database
Proteolytic eventsCutDB database (19 cleavages)
Activity statushuman: active (Kessler, 2004)
mouse: active (Scott et al., 2000)
PhysiologyCleaves C-terminal propeptide in maturation of type 1 procollagen.
KnockoutMice homozygous null for procollagen C-proteinase and mammalian tolloid-like 1 protein have been described (Pappano et al., 2003).
Pharmaceutical relevanceConsidered to be a drug target for fibrosis (Robinson et al., 2003).
Other databases TREEFAMhttp://www.treefam.org/family/TF314351
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/m/q/gansScissile bondD/deq/pa/- (based on 41 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 1 1 10 0 2 1 7
Pro 2 3 1 0 0 0 14 3
Ala 1 3 1 9 1 3 9 5
Val 4 1 4 0 0 1 1 0
Leu 3 2 2 1 0 0 1 3
Ile 1 2 1 0 0 0 0 1
Met 0 11 3 0 0 0 1 1
Phe 5 4 0 0 0 0 1 0
Tyr 6 7 2 0 0 0 0 2
Trp 0 1 0 0 0 0 1 0
Ser 5 3 4 6 1 2 1 3
Thr 1 0 1 0 1 2 4 1
Cys 1 0 1 0 0 0 0 0
Asn 1 0 0 6 0 0 2 5
Gln 2 1 13 4 3 6 0 4
Asp 2 0 0 1 35 13 1 0
Glu 2 1 1 2 0 10 4 2
Lys 0 0 0 1 0 0 0 1
Arg 3 1 5 1 0 2 0 2
His 0 0 1 0 0 0 0 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
BMP1 8p21 ENSG00000168487 649 BMP1 112264
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Bmp1 14:D1 ENSMUSG00000022098 12153 MGI:88176