Summary for peptidase M12.133: fibrolase

Summary Alignment Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Namefibrolase
Other namesAlfimeprase, copperhead venom fibrinolytic proteinase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.133
Holotypefibrolase (Agkistrodon contortrix contortrix), Uniprot accession P28891 (peptidase unit: 1-203), MERNUM MER0001130
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00180
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.72
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
PhysiologyLikely role in snake venom toxicity, preventing blood coagulation by destruction of fibrin and fibrinogen.
Pharmaceutical relevancePotential target for vaccine development.