Summary for peptidase M12.136: leucolysin

Summary Distribution Literature Substrates

 

Names
MEROPS Nameleucolysin
Other namesAgkistrodon piscivorus leucostoma venom endopeptidase, Leucostoma neutral proteinase, Leucostoma peptidase A, piscivorase
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.136
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.6
EnzymologyBRENDA database
PhysiologyLikely role in snake venom toxicity. Hemorrhagic. Disrupts vascular basement membrane.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/GScissile bondf/-/-/- (based on 16 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 1 1 9 0 0 2 0
Pro 0 0 0 0 0 0 0 1
Ala 0 0 0 1 0 0 0 1
Val 1 2 0 0 1 1 0 1
Leu 2 0 0 1 3 0 1 0
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 0 2 4 1 0 1
Tyr 0 0 0 0 3 2 1 0
Trp 0 0 0 1 1 0 0 0
Ser 0 0 1 0 0 0 0 1
Thr 0 0 0 0 0 0 1 1
Cys 0 0 0 0 0 0 0 0
Asn 0 1 0 0 0 1 0 0
Gln 0 0 1 0 0 0 1 0
Asp 0 0 0 0 0 0 0 0
Glu 1 1 1 0 1 0 1 0
Lys 0 0 0 0 2 0 0 0
Arg 0 1 1 0 1 1 0 0
His 0 0 0 2 0 0 0 1