Summary for peptidase M12.138: jararhagin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namejararhagin
Other namesbatroxhagin (Bothrops atrox), HF2-proteinase, jararafibrase I, venom endopeptidase Bothrops jararaca
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.138
Holotypejararhagin (Bothrops jararaca), Uniprot accession P30431 (peptidase unit: 153-355), MERNUM MER0001138
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00181
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.73
EnzymologyBRENDA database
Proteolytic eventsCutDB database (27 cleavages)
PhysiologyLikely role in snake venom toxicity. Hemorrhagic, anticoagulant.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/eas/-Scissile bondlfav/-/-/- (based on 40 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 4 5 3 0 1 3 2
Pro 2 2 0 2 0 0 0 7
Ala 1 4 7 10 5 2 5 2
Val 3 3 2 0 5 7 2 4
Leu 4 2 5 1 16 4 2 2
Ile 3 2 0 0 0 2 0 5
Met 1 1 1 1 3 1 1 1
Phe 0 2 0 2 7 0 2 1
Tyr 0 1 0 1 3 4 0 0
Trp 1 0 0 0 0 0 0 1
Ser 1 2 7 5 0 4 3 4
Thr 3 1 1 3 0 3 6 2
Cys 1 1 0 0 0 1 1 0
Asn 1 0 0 1 0 1 1 1
Gln 1 0 0 0 0 3 0 1
Asp 5 0 2 1 0 0 1 0
Glu 5 5 8 1 1 2 3 2
Lys 3 5 2 5 0 3 8 1
Arg 2 4 0 2 0 2 0 3
His 1 1 0 2 0 0 2 0