Summary for peptidase M12.141: adamalysin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors


MEROPS Nameadamalysin
Other namesadamalysin II, Crotalus adamanteus (eastern diamondback rattlesnake) venom metalloendopeptidase, proteinase H, proteinase I, proteinase II
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.141
Holotypeadamalysin (Crotalus adamanteus), Uniprot accession P34179 (peptidase unit: 1-203), MERNUM MER0001125
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00182
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
PhysiologyLikely role in snake venom toxicity. Not hemorrhagic, but inactivates serpins.