Summary for peptidase M12.142: atrolysin A

Summary Alignment Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Nameatrolysin A
Other namesCrotalus atrox venom metalloendopeptidase a
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.142
Holotypeatrolysin A (Crotalus atrox), Uniprot accession Q92043 (peptidase unit: 1-202), MERNUM MER0002419
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00183
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.1
EnzymologyBRENDA database
Proteolytic eventsCutDB database (2 cleavages)
PhysiologyLikely role in snake venom toxicity. Potent hemorrhagic toxin, degrading vascular basement membrane.