Summary for peptidase M12.143: atrolysin B

Summary Alignment Sequences Sequence features Distribution Literature Substrates Inhibitors


MEROPS Nameatrolysin B
Other namesCrotalus atrox metalloendopeptidase b, Crotalus atrox hemorragic toxin b
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.143
Holotypeatrolysin B (Crotalus atrox), Uniprot accession Q90391 (peptidase unit: 191-393), MERNUM MER0001410
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00184
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase
EnzymologyBRENDA database
PhysiologyLikely role in snake venom toxicity. Some hemorrhagic activity against capillary basement membrane.