Summary for peptidase M12.153: fibrinolytic peptidase (Philodryas olfersii)

Summary Distribution Literature Substrates Inhibitors

 

Names
MEROPS Namefibrinolytic peptidase (Philodryas olfersii)
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.153
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
PhysiologyLikely role in snake venom toxicity. Hemorrhagic; degrades fibrin and fibrinogen.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternElv/agv/els/hayScissile bondL/VY/el/agv (based on 15 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 4 1 0 0 0 1 4
Pro 0 0 0 0 0 0 0 1
Ala 0 4 0 4 0 0 0 4
Val 1 4 0 0 0 8 0 4
Leu 4 0 4 0 13 0 4 0
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 1 1 1 0 0 0
Tyr 0 0 0 4 0 5 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 4 0 0 0 0 1
Thr 0 0 0 0 0 0 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 1 0 0 0 0 0 0
Gln 0 0 1 0 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 5 0 4 0 0 0 4 0
Lys 0 0 0 0 0 0 0 0
Arg 0 1 0 1 0 0 0 0
His 0 0 0 5 0 0 0 0