Summary for peptidase M12.208: ADAM8 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS NameADAM8 peptidase
Other namesMS2, mCD158, CD156
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.208
HolotypeADAM8 peptidase (Homo sapiens), Uniprot accession P78325 (peptidase unit: 196-400), MERNUM MER0003902
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (8 cleavages)
Activity statushuman: active (Schlomann et al., 2002)
mouse: putative
KnockoutMice deficient in ADAM8 showed no distinct phenotype (Kelly et al., 2005).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/ADAM8
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/av/a/apScissile bondQsvfg/r/ls/r (based on 23 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 0 0 1 2 2 0 0
Pro 4 3 0 4 0 0 1 2
Ala 1 7 6 10 0 3 3 0
Val 2 4 1 1 3 0 2 2
Leu 3 1 4 0 0 0 6 2
Ile 0 0 0 0 0 0 0 0
Met 0 0 1 0 0 0 0 0
Phe 1 0 1 2 2 0 1 0
Tyr 0 0 0 0 0 1 0 0
Trp 0 1 0 0 0 0 0 0
Ser 3 2 0 2 4 3 5 3
Thr 0 0 0 0 0 1 0 0
Cys 0 0 0 0 0 0 0 0
Asn 1 0 0 0 0 0 0 0
Gln 0 1 4 1 10 2 2 3
Asp 1 0 0 0 0 0 0 0
Glu 1 1 1 1 0 0 1 0
Lys 1 0 2 0 0 4 0 1
Arg 1 3 1 0 0 6 1 4
His 0 0 1 1 0 1 0 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ADAM8 10q26.3 ENSG00000151651 101 ADAM8 602267
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Adam8 7:F3-F5 ENSMUSG00000025473 11501 MGI:107825