Summary for peptidase M12.209: ADAM9 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Pharma

 

Names
MEROPS NameADAM9 peptidase
Other namesADAM 19 [obs.], MDC9, meltrin gamma, metalloproteinase and disintegrin dendritic antigen marker, metalloproteinase 12
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.209
HolotypeADAM9 peptidase (Mus musculus), Uniprot accession Q61072 (peptidase unit: 208-406), MERNUM MER0003081
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00191
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (7 cleavages)
Activity statushuman: active (Blobel, 2004)
mouse: active (by similarity) (Weskamp et al., 2002)
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/ADAM9
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternpe/pva/avlr/ashScissile bondsqal/s/lr/r (based on 18 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 0 0 1 0 0 0 1
Pro 5 6 0 0 0 2 0 2
Ala 2 4 4 7 3 2 1 1
Val 2 5 4 0 0 2 2 2
Leu 0 0 3 0 2 2 6 2
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 1 1 0 0 0 0 0
Tyr 0 0 0 2 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 2 0 0 4 7 7 2 0
Thr 0 0 0 0 1 0 0 1
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 2
Gln 0 0 0 0 4 0 1 0
Asp 0 0 0 0 0 0 0 0
Glu 3 0 0 0 0 0 0 0
Lys 0 0 0 0 0 2 1 0
Arg 1 1 3 1 0 0 4 5
His 0 0 2 3 0 1 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ADAM9 8p11.22 ENSG00000168615 8754 ADAM9 602713
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Adam9 8:A2 ENSMUSG00000031555 11502 MGI:105376