Summary for peptidase M12.210: ADAM10 peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS NameADAM10 peptidase
Other namesmyelin-associated disintegrin metalloproteinase, MADM, mammalian kuzbanian protein
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.210
HolotypeADAM10 peptidase (Bos taurus), Uniprot accession Q10741 (peptidase unit: 202-456), MERNUM MER0001139
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00192
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.81
EnzymologyBRENDA database
Proteolytic eventsCutDB database (18 cleavages)
PhysiologyMyelin-degrading activity.
KnockoutADAM 10-deficient mouse embryos die at day 9.5 with multiple defects of the developing central nervous system, somites, and cardiovascular system (Hartmann et al., 2002).
Pharmaceutical relevancePotential drug target for demyelinating disease. May play an important role in Notch signalling (Hartmann et al., 2002).
Pathways KEGGAlzheimer's disease
KEGGEpithelial cell signaling in Helicobacter pylori infection
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/ADAM10
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/aScissile bondv/-/s/- (based on 40 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 4 1 1 2 1 1 6 0
Pro 2 4 0 3 0 0 1 0
Ala 0 8 5 10 1 3 3 2
Val 3 5 4 1 10 9 2 7
Leu 4 1 3 0 5 3 1 0
Ile 0 2 2 3 2 4 4 1
Met 0 1 2 2 3 0 1 0
Phe 0 2 0 0 1 0 2 3
Tyr 1 2 0 1 0 1 0 0
Trp 0 0 0 0 0 0 0 0
Ser 7 4 2 0 2 1 12 3
Thr 3 1 0 5 2 2 4 1
Cys 0 0 0 0 0 0 2 0
Asn 3 0 2 0 0 1 0 0
Gln 0 2 9 2 6 1 0 8
Asp 1 0 1 0 0 0 1 2
Glu 2 1 4 1 0 1 0 2
Lys 2 1 2 3 1 7 1 4
Arg 1 0 1 2 4 5 0 1
His 6 5 1 5 0 1 0 3
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ADAM10 15q21.3 ENSG00000137845 102 ADAM10 602192
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Adam10 9:D ENSMUSG00000054693 11487 MGI:109548