Summary for peptidase M12.212: ADAM12 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS NameADAM12 peptidase
Other namesmeltrin alpha
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.212
HolotypeADAM12 peptidase (Mus musculus), Uniprot accession Q61824 (peptidase unit: 208-414), MERNUM MER0002410
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00194
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: active (Wewer, 2004)
mouse: active (Kurisaki et al., 2003)
PhysiologyADAM12 is an IGFBP-3 and IGFBP-5 protease, and has been described as a promising marker for Down syndrome (Laigaard et al., 2003).
KnockoutNull mice generated by gene targeting show increased embryonic mortality, but most homozygous individuals appear normal (Kurisaki et al., 2003).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/ADAM12
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ADAM12 10q26 ENSG00000148848 8038 ADAM12 602714
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Adam12 7:F4 ENSMUSG00000054555 11489 MGI:105378