Summary for peptidase M12.218: ADAM20 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Mouse EST

 

Names
MEROPS NameADAM20 peptidase
Name and HistoryADAM20 and ADAM21 were first sequenced from a human testis cDNA library (Van Huijsduijnen, 1998).
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.218
HolotypeADAM20 peptidase (Homo sapiens), Uniprot accession O43506 (peptidase unit: 203-399), MERNUM MER0004725
History Identifier created: MEROPS 3.1 (22 December 1998)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
SpecificityThe protein has not been characterized biochemically.
StructureThe ADAM20 sequence consists of a propeptide, a metallopeptidase, a disintegrin and an ADAM-CR domain, a transmembrane region and a cytoplasmic tail (Van Huijsduijnen, 1998). The sequence also contains the tripeptide Val-Gly-Glu which could bind the egg integrin receptor, a prerequisite for sperm-egg cell fusion. There is no furin-like processing site.
PhysiologyIf ADAM20 is required for sperm-egg fusion, then it is the functional equivalent of ADAM1, which is absent in humans.
RNA splicingThe ADAM20 gene lacks introns (Poindexter et al., 1999), which may indicate it is a pseudogene.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/ADAM20
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ADAM20 14q24.1 ENSG00000134007 8748 ADAM20 603712