Summary for peptidase M12.222: ADAMTS1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Pharma

 

Names
MEROPS NameADAMTS1 peptidase
Other namesADAMTS, METH-1, KIAA1346 protein (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.222
HolotypeADAMTS1 peptidase (Homo sapiens), Uniprot accession Q9UHI8 (peptidase unit: 253-467), MERNUM MER0005546
History Identifier created: MEROPS 3.21 (12 May 1999)
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00197
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (6 cleavages)
Activity statushuman: active (Kuno, 2004)
mouse: active (Russell et al., 2003)
KnockoutForty-five percent of newborn ADAMTS1 endopeptidase null mice died, probably as a result of kidney malformation. Surviving females were subfertile (Mittaz et al., 2004).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/ADAMTS1
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/aes/-/EScissile bondal/rg/grq/g (based on 13 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 1 0 2 3 6 4
Pro 0 1 0 0 0 0 0 1
Ala 0 4 2 0 4 0 1 1
Val 3 0 0 0 0 0 0 1
Leu 1 1 1 0 4 1 0 0
Ile 2 0 0 0 0 1 0 0
Met 0 0 0 0 0 0 0 0
Phe 1 0 1 0 1 1 0 0
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 1 0 0 0 0 0
Ser 1 3 1 0 1 0 0 2
Thr 2 0 0 0 0 0 0 2
Cys 0 0 0 0 0 0 0 0
Asn 0 0 1 1 0 0 0 0
Gln 0 0 3 0 1 0 2 0
Asp 0 0 0 0 0 0 0 0
Glu 2 4 2 12 0 0 1 0
Lys 1 0 0 0 0 1 0 0
Arg 0 0 0 0 0 6 3 2
His 0 0 0 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ADAMTS1 21q22.1-q22 ENSG00000154734 9510 ADAMTS1 605174
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Adamts1 16:C3-C5 ENSMUSG00000022893 11504 MGI:109249