Summary for peptidase M12.235: ADAMTS10 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Inhibitors


MEROPS NameADAMTS10 peptidase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.235
HolotypeADAMTS10 peptidase (Homo sapiens), Uniprot accession Q9H324 (peptidase unit: 234-457), MERNUM MER0014331
History Identifier created: MEROPS 5.5 (16 June 2001)
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: putative
mouse: putative
KnockoutA study of the autosomal recessive Weill-Marchesani syndrome led to the conclusion that ADAMTS10 endopeptidase plays a major role in growth and in skin, lens, and heart development in humans (Dagoneau et al., 2004).
Other databases WIKIPEDIA
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ADAMTS10 19p13.3 ENSG00000142303 81794 ADAMTS10
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Adamts10 17:B1 ENSMUSG00000024299 224697 MGI:2449112