Summary for peptidase M12.235: ADAMTS10 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Inhibitors

 

Names
MEROPS NameADAMTS10 peptidase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.235
HolotypeADAMTS10 peptidase (Homo sapiens), Uniprot accession Q9H324 (peptidase unit: 234-457), MERNUM MER0014331
History Identifier created: MEROPS 5.5 (16 June 2001)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: putative
mouse: putative
KnockoutA study of the autosomal recessive Weill-Marchesani syndrome led to the conclusion that ADAMTS10 endopeptidase plays a major role in growth and in skin, lens, and heart development in humans (Dagoneau et al., 2004).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/ADAMTS10
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ADAMTS10 19p13.3 ENSG00000142303 81794 ADAMTS10
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Adamts10 17:B1 ENSMUSG00000024299 224697 MGI:2449112