Summary for peptidase M12.244: ADAM33 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS NameADAM33 peptidase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.244
HolotypeADAM33 peptidase (Mus musculus), Uniprot accession Q923W9 (peptidase unit: 207-410), MERNUM MER0015147
History Identifier created: MEROPS 6.0 (30 August 2002)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (3 cleavages)
Activity statushuman: active (Zou et al., 2004)
mouse: putative
Pharmaceutical relevanceThere is evidence that polymorphisms in ADAM33 predispose to asthma (Van Eerdewegh et al., 2002; Howard et al., 2003; Werner et al., 2004).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/ADAM33
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ADAM33 20p13 ENSG00000149451 80332 607114
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Adam33 2:F2 ENSMUSG00000027318 110751 MGI:1341813