Summary for peptidase homologue M12.950: ADAM2 protein

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST

 

Names
MEROPS NameADAM2 protein
Other namesfertilin beta, PH-30 beta
Name and HistoryThe ADAM2 protein is a non-peptidase homologue that exists as a heterodimer with ADAM1 on the apical surface of sperm (Wolfsberg et al., 1993).
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.950
HolotypeADAM2 protein (Homo sapiens), Uniprot accession Q99965 (peptidase unit: 160-375), MERNUM MER0003090
History Identifier created: MEROPS 5.1 (22 June 2000)
Activity
Catalytic typeNon-peptidase homologue
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: inactive
mouse: inactive
SpecificityBecause the HEXXH zinc-binding motif is not conserved, ADAM2 is not a peptidase.
StructureADAM2 consists of an activation peptide, a reprolysin-like peptidase domain, a disintegrin domain, a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane region and a cytoplasmic tail (Waters & White, 1997).
PhysiologyADAM2 functions in sperm adhesion and fusion with the egg plasma membrane (Ramarao et al., 1996). ADAM2 is processed during epididymal maturation, releasing N- and C-terminal propeptides. Mature mouse ADAM2 is a 45 kDa protein (Cho et al., 2000).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/ADAM2
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ADAM2 8p11.2 ENSG00000104755 2515 ADAM2 601533
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Adam2 14:D1 ENSMUSG00000022039 11495 MGI:1340894