Summary for peptidase M13.002: endothelin-converting enzyme 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameendothelin-converting enzyme 1
Other namesECE-1
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M13 >> Subfamily (none) >> M13.002
Holotypeendothelin-converting enzyme 1 (Bos taurus), Uniprot accession P42891 (peptidase unit: 78-754), MERNUM MER0001056
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00202
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.71
EnzymologyBRENDA database
Proteolytic eventsCutDB database (21 cleavages)
PhysiologyEctoenzyme activating endothelin precursor.
KnockoutNull mutation of the gene in mouse resulted in embryos that exhibited craniofacial and cardiac abnormalities closely similar to those in mice deficient in endothelin-1 or endothelin A receptor (Yanagisawa et al., 1998), and mutations are associated with Hirschsprung disease in humans (Hofstra et al., 1999).
Pharmaceutical relevanceDrug target in hypertension.
Other databases TREEFAMhttp://www.treefam.org/family/TF315192
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bondflv/-/-/- (based on 34 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 4 2 0 2 0 1 1 1
Pro 2 2 0 4 1 1 2 4
Ala 0 1 2 2 2 1 2 2
Val 1 2 4 1 5 4 2 3
Leu 1 3 3 4 6 3 5 4
Ile 0 4 3 1 4 3 0 0
Met 0 0 0 0 0 2 0 1
Phe 1 5 1 3 9 2 2 2
Tyr 2 0 2 3 4 1 1 1
Trp 0 0 0 3 0 1 1 0
Ser 1 3 5 1 1 1 1 3
Thr 1 0 0 1 0 0 3 0
Cys 3 2 0 0 2 1 2 1
Asn 0 0 0 0 0 3 1 2
Gln 1 2 3 1 0 0 0 0
Asp 4 2 1 1 0 0 1 3
Glu 2 1 2 2 0 2 3 0
Lys 2 0 3 1 0 2 0 2
Arg 2 2 2 2 0 3 1 0
His 4 2 2 2 0 3 3 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ECE1 1p36.1 ENSG00000117298 1889 ECE1 600423
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ece1 4:D3 ENSMUSG00000057530 230857 MGI:1101357