Summary for peptidase M13.008: neprilysin-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Nameneprilysin-2
Other namessoluble neutral endopeptidase, soluble secreted endopeptidase, SEP, neprilysin-like peptidase, NEPLP, NL1 protein, MMEL1 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M13 >> Subfamily (none) >> M13.008
Holotypeneprilysin-2 (Homo sapiens), Uniprot accession Q495T6 (peptidase unit: 84-779), MERNUM MER0013406
History Identifier created: MEROPS 5.1 (22 June 2000)
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00204
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Carpentier et al., 2004)
mouse: active (Ghaddar et al., 2000)
Other databases TREEFAMhttp://www.treefam.org/family/TF315192
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternhd/-/-/gScissile bondflv/-/f/fa (based on 16 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 0 3 6 0 0 1 1
Pro 0 1 0 2 0 0 2 1
Ala 0 0 0 0 0 0 0 2
Val 0 0 1 0 3 2 0 0
Leu 0 0 0 2 4 2 1 1
Ile 0 2 1 0 1 0 0 0
Met 0 0 1 0 0 3 0 0
Phe 0 2 1 0 7 3 4 4
Tyr 1 4 1 1 0 0 1 0
Trp 1 0 0 1 1 0 0 0
Ser 0 1 1 1 0 0 0 0
Thr 0 0 0 0 0 0 1 0
Cys 0 1 0 0 0 0 0 0
Asn 0 0 1 0 0 1 0 0
Gln 1 2 3 1 0 0 0 0
Asp 3 0 0 0 0 0 1 0
Glu 0 0 0 0 0 0 0 0
Lys 1 0 2 2 0 0 0 0
Arg 0 1 0 0 0 3 0 0
His 4 2 1 0 0 2 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMEL1 1p36 ENSG00000142606 79258
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Sep 4:E2 ENSMUSG00000029058 27390 MGI:1351603