Summary for peptidase M14.003: carboxypeptidase B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma


MEROPS Namecarboxypeptidase B
Other namescarboxypeptidase B1, CPB1 g.p. (Homo sapiens), pancreatic carboxypeptidase B, protaminase, tissue carboxypeptidase B
Domain architecture
MEROPS Classification
Classification Clan MC >> Subclan (none) >> Family M14 >> Subfamily A >> M14.003
Holotypecarboxypeptidase B (Bos taurus), Uniprot accession P00732 (peptidase unit: 1-306), MERNUM MER0001196
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00208
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.17 (Metallocarboxypeptidases) >> Peptidase
EnzymologyBRENDA database
Activity statushuman: active (Aviles & Vendrell, 2004)
mouse: active (by similarity)
PhysiologyRole in mammalian alimentary digestion.
Pathways KEGGPancreatic secretion
KEGGProtein digestion and absorption
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CPB1 3q24 ENSG00000153002 1360 CPB1 114852
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Cpb1 3:A2 ENSMUSG00000011463 76703 MGI:1923953