Summary for peptidase M14.003: carboxypeptidase B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecarboxypeptidase B
Other namescarboxypeptidase B1, CPB1 g.p. (Homo sapiens), pancreatic carboxypeptidase B, protaminase, tissue carboxypeptidase B
Domain architecture
MEROPS Classification
Classification Clan MC >> Subclan (none) >> Family M14 >> Subfamily A >> M14.003
Holotypecarboxypeptidase B (Bos taurus), Uniprot accession P00732 (peptidase unit: 1-306), MERNUM MER0001196
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00208
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.17 (Metallocarboxypeptidases) >> Peptidase 3.4.17.2
EnzymologyBRENDA database
Activity statushuman: active (Aviles & Vendrell, 2004)
mouse: active (by similarity)
PhysiologyRole in mammalian alimentary digestion.
Pathways KEGGPancreatic secretion
KEGGProtein digestion and absorption
Other databases TREEFAMhttp://www.treefam.org/family/TF317197
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CPB1 3q24 ENSG00000153002 1360 CPB1 114852
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Cpb1 3:A2 ENSMUSG00000011463 76703 MGI:1923953