Summary for peptidase M14.004: carboxypeptidase N

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecarboxypeptidase N
Other namesanaphylatoxin inactivator, arginine carboxypeptidase, carboxypeptidase K, CPN1 g.p. (Homo sapiens), creatine kinase conversion factor, kininase I, lysine carboxypeptidase, plasma carboxypeptidase B
Domain architecture
MEROPS Classification
Classification Clan MC >> Subclan (none) >> Family M14 >> Subfamily B >> M14.004
Holotypecarboxypeptidase N (Homo sapiens), Uniprot accession P15169 (peptidase unit: 15-340), MERNUM MER0001198
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00209
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.17 (Metallocarboxypeptidases) >> Peptidase 3.4.17.3
EnzymologyBRENDA database
Proteolytic eventsCutDB database (4 cleavages)
PhysiologyDestroys vasoactive peptides in the circulation. May affect binding of plasminogen to cells.
Other databases TREEFAMhttp://www.treefam.org/family/TF315592
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/lgk/-Scissile bondKR/-/-/- (based on 15 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 2 2 2 0 0 0 0
Pro 0 0 1 0 0 0 0 0
Ala 2 2 0 4 0 0 0 0
Val 1 0 0 0 0 0 0 0
Leu 1 0 6 2 0 0 0 0
Ile 0 0 0 1 0 0 0 0
Met 1 0 0 0 0 0 0 0
Phe 1 0 0 1 0 0 0 0
Tyr 0 1 0 1 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 1 2 0 0 0 0 0 0
Thr 1 0 1 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 1 0 0 0 0
Gln 1 3 0 1 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 1 0 1 0 0 0 0
Lys 3 1 2 1 8 0 0 0
Arg 0 0 0 0 7 0 0 0
His 0 0 0 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CPN1 10 ENSG00000120054 1369 CPN1 603103