Summary for peptidase M14.006: carboxypeptidase M

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecarboxypeptidase M
Other namesrenal carboxypeptidase, urinary carboxypeptidase B
Domain architecture
MEROPS Classification
Classification Clan MC >> Subclan (none) >> Family M14 >> Subfamily B >> M14.006
Holotypecarboxypeptidase M (Homo sapiens), Uniprot accession P14384 (peptidase unit: 12-313), MERNUM MER0001205
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00211
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.17 (Metallocarboxypeptidases) >> Peptidase 3.4.17.12
EnzymologyBRENDA database
Proteolytic eventsCutDB database (3 cleavages)
Activity statushuman: active (Skidgel, 2004)
mouse: putative (Rehli et al., 2000)
PhysiologyMay degrade bioactive peptides.
Other databases TREEFAMhttp://www.treefam.org/family/TF315592
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bondRK/-/-/- (based on 11 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 2 0 2 0 0 0 0
Pro 0 1 1 0 0 0 0 0
Ala 0 1 0 2 0 0 0 0
Val 0 0 0 0 0 0 0 0
Leu 0 0 1 3 0 0 0 0
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 1 0 0 0 0
Phe 1 0 2 1 0 0 0 0
Tyr 0 0 0 1 0 0 0 0
Trp 1 1 0 0 0 0 0 0
Ser 0 2 0 0 0 0 0 0
Thr 1 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 1 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 0 1 0 0 0 0 0
Lys 1 0 2 0 5 0 0 0
Arg 1 0 0 0 6 0 0 0
His 0 0 0 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CPM 12q15 ENSG00000135678 1368 CPM 114860
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
5730456K23Rik 10:D2 ENSMUSG00000020183 70574 MGI:1917824