Summary for peptidase M16.001: pitrilysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namepitrilysin
Other namesEscherichia coli protease III, Escherichia coli protease Pi
Domain architecture
MEROPS Classification
Classification Clan ME >> Subclan (none) >> Family M16 >> Subfamily A >> M16.001
Holotypepitrilysin (Escherichia coli), Uniprot accession P05458 (peptidase unit: 24-232), MERNUM MER0001222
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00220
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.55
EnzymologyBRENDA database
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 23 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 2 2 2 0 1 0 1
Pro 1 0 0 0 0 0 1 1
Ala 1 1 0 0 0 1 2 1
Val 2 3 1 0 0 1 0 1
Leu 0 2 5 4 3 2 1 1
Ile 0 0 0 0 2 0 2 2
Met 0 1 0 0 1 2 1 1
Phe 1 4 4 3 1 1 2 1
Tyr 2 1 1 3 1 0 0 1
Trp 0 0 0 1 0 1 0 0
Ser 1 0 3 1 1 3 3 2
Thr 2 2 1 1 2 1 0 2
Cys 1 0 0 0 1 0 0 0
Asn 2 0 2 0 2 3 1 0
Gln 2 0 0 0 1 2 2 2
Asp 0 0 1 0 0 0 2 0
Glu 2 0 0 0 0 0 1 1
Lys 2 4 1 3 4 2 1 2
Arg 1 1 1 3 4 2 1 0
His 0 0 1 2 0 0 0 1