Summary for peptidase M16.003: mitochondrial processing peptidase beta-subunit

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Namemitochondrial processing peptidase beta-subunit
Other namesMPP, processing enhancing protein
Domain architecture
MEROPS Classification
Classification Clan ME >> Subclan (none) >> Family M16 >> Subfamily B >> M16.003
Holotypemitochondrial processing peptidase beta-subunit (Saccharomyces cerevisiae), Uniprot accession P10507 (peptidase unit: 30-245), MERNUM MER0001229
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00222
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.64
EnzymologyBRENDA database
PhysiologyProcesses N-terminal targetting peptides from mitochondrial proteins during import.
Other databases TREEFAMhttp://www.treefam.org/family/TF105032
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/r/R/-Scissile bondylfa/Sa/-/- (based on 81 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 1 1 6 3 4 2 8
Pro 5 1 0 2 1 1 4 4
Ala 16 9 6 9 9 10 9 13
Val 7 13 1 2 2 2 4 4
Leu 15 6 4 8 18 0 3 5
Ile 1 2 0 0 2 1 1 2
Met 2 1 0 4 1 0 0 0
Phe 2 1 0 11 15 0 0 0
Tyr 0 1 0 6 25 0 1 1
Trp 0 0 0 1 0 1 1 1
Ser 6 11 2 11 3 39 15 11
Thr 3 5 1 6 0 6 18 6
Cys 1 1 0 3 1 1 2 0
Asn 2 0 3 5 0 0 5 5
Gln 8 2 0 0 1 0 5 3
Asp 0 0 0 0 0 2 4 3
Glu 1 0 1 0 0 4 2 3
Lys 2 6 0 1 0 0 2 6
Arg 4 20 62 3 0 6 0 1
His 3 1 0 3 0 4 3 3
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PMPCB 7q22.1 ENSG00000105819 9512 PMPCB 603131
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
3110004O18Rik 5:A3 ENSMUSG00000029017 73078 MGI:1920328