Summary for peptidase M16.005: nardilysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Namenardilysin
Other namesN-arginine dibasic convertase, NRD1 g.p. (Homo sapiens), NRD-convertase, somatostatin-28 convertase
Domain architecture
MEROPS Classification
Classification Clan ME >> Subclan (none) >> Family M16 >> Subfamily A >> M16.005
Holotypenardilysin (Rattus norvegicus), Uniprot accession P47245 (peptidase unit: 222-428), MERNUM MER0001220
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00223
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.61
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Chesneau et al., 2004)
mouse: active (Ma et al., 2002)
PhysiologyNardilysin is reported to contain a bipartite nuclear localization signal that permits the enzyme to cycle between the nucleus and cytoplasm (Ma et al., 2005).
Other databases TREEFAMhttp://www.treefam.org/family/TF106274
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
NRD1 1p32.2-p32.1 ENSG00000078618 4898 602651
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Nrd1 4:C7 ENSMUSG00000053510 230598 MGI:1201386