Summary for peptidase M16.005: nardilysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors


MEROPS Namenardilysin
Other namesN-arginine dibasic convertase, NRD1 g.p. (Homo sapiens), NRD-convertase, somatostatin-28 convertase
Domain architecture
MEROPS Classification
Classification Clan ME >> Subclan (none) >> Family M16 >> Subfamily A >> M16.005
Holotypenardilysin (Rattus norvegicus), Uniprot accession P47245 (peptidase unit: 222-428), MERNUM MER0001220
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00223
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Chesneau et al., 2004)
mouse: active (Ma et al., 2002)
PhysiologyNardilysin is reported to contain a bipartite nuclear localization signal that permits the enzyme to cycle between the nucleus and cytoplasm (Ma et al., 2005).
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
NRD1 1p32.2-p32.1 ENSG00000078618 4898 602651
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Nrd1 4:C7 ENSMUSG00000053510 230598 MGI:1201386