Summary for peptidase M17.001: leucine aminopeptidase 3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameleucine aminopeptidase 3
Other namescytosol aminopeptidase, cytosolic Cys-Gly dipeptidase, HlLAP (Haemaphysalis longicornis), LAP3 g.p. (Homo sapiens), Lap3 g.p. (Mus musculus), leucyl aminopeptidase, leucyl peptidase, peptidase S, PEPS
Domain architecture
MEROPS Classification
Classification Clan MF >> Subclan (none) >> Family M17 >> Subfamily (none) >> M17.001
Holotypeleucine aminopeptidase 3 (Bos taurus), Uniprot accession P00727 (peptidase unit: 33-519), MERNUM MER0001235
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00224
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.1
EnzymologyBRENDA database
Activity statushuman: active (Strater & Lipscomb, 2004)
mouse: active (by similarity to rat) (Josch et al., 2003)
PhysiologyLikely role in cytoplasmic degradation of oligopeptides.
Pathways KEGGGlutathione metabolism
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Leucyl_aminopeptidase
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
LAP3 4p15.33 ENSG00000002549 51056 LAP3 170250
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Lap3 5:B3 ENSMUSG00000039682 66988 MGI:1914238