Summary for peptidase M18.002: aspartyl aminopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameaspartyl aminopeptidase
Other namesApe4 g.p. (Saccharomyces cerevisiae), DNPEP g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan MH >> Subclan (none) >> Family M18 >> Subfamily (none) >> M18.002
Holotypeaspartyl aminopeptidase (Mus musculus), Uniprot accession Q9Z2W0 (peptidase unit: 9-473), MERNUM MER0003374
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00227
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.21
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Wilk, 2004)
mouse: active (by similarity to human) (Wilk et al., 1998)
Other databases TREEFAMhttp://www.treefam.org/family/TF300487
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/DScissile bond-/-/-/- (based on 10 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 0 0 0
Pro 0 0 0 0 0 1 0 0
Ala 0 0 0 0 2 0 0 0
Val 0 0 0 0 0 1 0 0
Leu 0 0 0 0 1 0 0 0
Ile 0 0 0 0 0 0 0 1
Met 0 0 0 0 0 0 0 0
Phe 0 0 0 0 1 1 0 0
Tyr 0 0 0 0 0 0 1 0
Trp 0 0 0 0 0 0 0 1
Ser 0 0 0 0 1 0 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 8 0 0 0 0
Glu 0 0 0 2 0 0 0 0
Lys 0 0 0 0 0 0 0 0
Arg 0 0 0 0 1 0 1 0
His 0 0 0 0 2 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
DNPEP 2q36.1 ENSG00000123992 23549 DNPEP
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Dnpep 1:C4 ENSMUSG00000026209 13437 MGI:1278328