Summary for peptidase M23.004: lysostaphin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors


MEROPS Namelysostaphin
Domain architecture
MEROPS Classification
Classification Clan MO >> Subclan (none) >> Family M23 >> Subfamily B >> M23.004
Holotypelysostaphin (Staphylococcus simulans), Uniprot accession P10547 (peptidase unit: 248-390), MERNUM MER0001419
History Identifier created: MEROPS 6.1 (10 January 2003)
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00235
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase
EnzymologyBRENDA database
BiotechnologyAn agent for lysis of staphylococcal cell walls in the laboratory.
Pharmaceutical relevanceLysostaphin is effective in treating experimental endophthalmitis mediated by methicillin-resistant Staphylococcus aureus (Dajcs et al., 2001; Dajcs et al., 2002). Its therapeutic value may be improved by conjugation with polyethylene glycol (Walsh et al., 2003). Lysostaphin cream eradicated Staphylococcus aureus nasal colonisation in a rat model (Kokai-Kun et al., 2003).