Summary for peptidase M24.001: methionyl aminopeptidase 1 (Escherichia-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namemethionyl aminopeptidase 1 (Escherichia-type)
Other namesmethionine aminopeptidase 1, methionyl aminopeptidase 1 (Escherichia coli), MetAP1 (Saccharomyces cerevisiae), MtMetAP1a (Mycobacterium tuberculosis), MtMetAP1c (Mycobacterium tuberculosis), peptidase M
Domain architecture
MEROPS Classification
Classification Clan MG >> Subclan (none) >> Family M24 >> Subfamily A >> M24.001
Holotypemethionyl aminopeptidase 1 (Escherichia-type) (Escherichia coli), Uniprot accession P0AE18 (peptidase unit: 1-264), MERNUM MER0001243
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00236
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.18
EnzymologyBRENDA database
Activity statushuman: active (Bradshaw et al., 2004)
mouse: active (by similarity)
PhysiologyProbable role in cotranslational removal of N-terminal methionine.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/MScissile bondsat/-/-/- (based on 978 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 45 17 22 33
Pro 0 0 0 0 80 10 47 42
Ala 0 0 0 0 295 48 40 54
Val 0 0 0 0 29 52 52 71
Leu 0 0 0 0 2 67 87 104
Ile 0 0 0 0 6 57 107 84
Met 0 0 0 977 6 21 16 5
Phe 0 0 0 0 4 33 41 41
Tyr 0 0 0 0 2 23 27 31
Trp 0 0 0 0 0 1 7 4
Ser 0 0 0 0 314 59 61 68
Thr 0 0 0 0 158 97 99 88
Cys 0 0 0 0 2 1 1 5
Asn 0 0 0 0 15 61 59 64
Gln 0 0 0 0 1 76 62 34
Asp 0 0 0 0 4 61 28 51
Glu 0 0 0 0 2 88 57 41
Lys 0 0 0 0 12 128 95 89
Arg 0 0 0 0 1 49 38 29
His 0 0 0 0 0 29 24 30
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
2q31.1 ENSG00000172878 254042
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Metap1 3:G3-41 ENSMUSG00000005813 75624 MGI:1922874