Summary for peptidase M24.002: methionyl aminopeptidase 2

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namemethionyl aminopeptidase 2
Other nameseukaryotic initiation factor 2 alpha binding protein p67, methionine aminopeptidase 2, peptidase M, MetAP2 (Saccharomyces cerevisiae)
Domain architecture
MEROPS Classification
Classification Clan MG >> Subclan (none) >> Family M24 >> Subfamily A >> M24.002
Holotypemethionyl aminopeptidase 2 (Homo sapiens), Uniprot accession P50579 (peptidase unit: 156-478), MERNUM MER0001728
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00237
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.18
EnzymologyBRENDA database
Activity statushuman: active (Bradshaw et al., 2004)
mouse: active (Turk et al., 1998)
PhysiologyProbable role in cotranslational removal of N-terminal methionine in protein synthesis.
Pharmaceutical relevanceTarget of drugs inhibiting angiogenesis, and the primary target of the potent angiogenesis inhibitors fumagillin and ovalicin (Endo et al., 2002). A rationally-designed reversible inhibitor suppressed the growth of several tumours (Wang et al., 2003).
Other databases TREEFAMhttp://www.treefam.org/family/TF300426
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/MScissile bondasvpt/-/-/- (based on 135 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 7 3 5 2
Pro 0 0 0 0 19 4 2 9
Ala 0 0 0 0 41 2 4 5
Val 0 0 0 0 25 10 17 8
Leu 0 0 0 0 0 5 10 12
Ile 0 0 0 0 0 6 7 8
Met 0 0 0 135 1 1 1 0
Phe 0 0 0 0 0 2 5 2
Tyr 0 0 0 0 0 4 9 6
Trp 0 0 0 0 0 2 2 0
Ser 0 0 0 0 27 8 8 5
Thr 0 0 0 0 15 13 11 14
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 6 6 8
Gln 0 0 0 0 0 1 7 2
Asp 0 0 0 0 0 10 2 9
Glu 0 0 0 0 0 26 17 19
Lys 0 0 0 0 0 23 13 18
Arg 0 0 0 0 0 7 7 4
His 0 0 0 0 0 1 1 3
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
METAP2 12q22 ENSG00000111142 10988 METAP2 601870